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Modular Peptide Growth Factors for Substrate‐Mediated Stem Cell Differentiation
Author(s) -
Lee Jae Sam,
Lee Jae Sung,
WagonerJohnson Amy,
Murphy William L.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901618
Subject(s) - peptide , peptide sequence , cyan , chemistry , osteocalcin , bone morphogenetic protein 2 , calcium , biochemistry , stereochemistry , microbiology and biotechnology , biophysics , crystallography , biology , physics , enzyme , alkaline phosphatase , organic chemistry , in vitro , gene , optics
The sequence specificity of the binding of a modular peptide growth factor (eBGa3) that contains a BMP2‐derived sequence and a mineral‐binding sequence inspired by osteocalcin to calcium ions of hydroxyapatite (HA) may be attributed in part to evolution of an α‐helical structure in the presence of HA, which allows for registration of γ‐carboxylated glutamic acid residues in the peptide (cyan) with calcium atoms (orange) in the HA crystal lattice.