Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties | Zendy

Sisson Adam L. | Zendy; Steinhilber Dirk | Zendy; Rossow Torsten | Zendy; Welker Pia | Zendy; Licha Kai | Zendy; Haag Rainer | Zendy

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Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties

Author(s) -

Sisson Adam L.,

Steinhilber Dirk,

Rossow Torsten,

Welker Pia,

Licha Kai,

Haag Rainer

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901583

Subject(s) - biocompatible material , nanotechnology , nanoparticle , particle (ecology) , chemistry , materials science , computer science , polymer science , engineering , biomedical engineering , biology , ecology

Gels for cells : A new method to produce biocompatible polyglycerol microgel nanoparticles with controllable size (25–100 nm, see picture, top) and a readily functionalizable surface is developed. Fluorescence imaging shows clear evidence for particle uptake by cells through endocytotic pathways and localization of the particles in the perinuclear region.

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