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Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties
Author(s) -
Sisson Adam L.,
Steinhilber Dirk,
Rossow Torsten,
Welker Pia,
Licha Kai,
Haag Rainer
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901583
Subject(s) - biocompatible material , nanotechnology , nanoparticle , particle (ecology) , chemistry , materials science , computer science , polymer science , engineering , biomedical engineering , biology , ecology
Gels for cells : A new method to produce biocompatible polyglycerol microgel nanoparticles with controllable size (25–100 nm, see picture, top) and a readily functionalizable surface is developed. Fluorescence imaging shows clear evidence for particle uptake by cells through endocytotic pathways and localization of the particles in the perinuclear region.