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Microfluidic Confinement of Single Cells of Bacteria in Small Volumes Initiates High‐Density Behavior of Quorum Sensing and Growth and Reveals Its Variability
Author(s) -
Boedicker James Q.,
Vincent Meghan E.,
Ismagilov Rustem F.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901550
Subject(s) - quorum sensing , pseudomonas aeruginosa , microfluidics , bacteria , biology , population , computational biology , computer science , microbiology and biotechnology , nanotechnology , biofilm , genetics , materials science , medicine , environmental health
One is a quorum : As few as one to three cells of Pseudomonas aeruginosa bacteria are confined in small volumes by the use of microfluidics. These small numbers of cells are able to activate quorum sensing (QS) pathways and achieve QS‐dependent growth. The results also show that at low numbers of cells, initiation of QS is highly variable within a clonal population.