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Me‐bipam for Enantioselective Ruthenium(II)‐Catalyzed Arylation of Aldehydes with Arylboronic Acids
Author(s) -
Yamamoto Yasunori,
Kurihara Kazunori,
Miyaura Norio
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901395
Subject(s) - phosphoramidite , enantioselective synthesis , ruthenium , denticity , ligand (biochemistry) , chemistry , catalysis , combinatorial chemistry , organic chemistry , receptor , crystal structure , biochemistry , dna , oligonucleotide
Ligand design by‐pam : A ruthenium‐catalyzed asymmetric arylation of aldehydes with arylboronic acids has been developed, giving chiral diarylmethanols in good yields. The use of a chiral bidentate phosphoramidite ligand (( R , R )‐Me‐bipam) led to excellent enantioselectivities.