Fast Attrition‐Enhanced Deracemization of Naproxen by a Gradual In Situ Feed | Zendy

Noorduin Wim L. | Zendy; Kaptein Bernard | Zendy; Meekes Hugo | Zendy; van Enckevort Willem J. P. | Zendy; Kellogg Richard M. | Zendy; Vlieg Elias | Zendy

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Fast Attrition‐Enhanced Deracemization of Naproxen by a Gradual In Situ Feed

Author(s) -

Noorduin Wim L.,

Kaptein Bernard,

Meekes Hugo,

van Enckevort Willem J. P.,

Kellogg Richard M.,

Vlieg Elias

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901386

Subject(s) - naproxen , grind , in situ , nonsteroidal , materials science , grinding , chemical engineering , process engineering , chemistry , nanotechnology , medicine , metallurgy , organic chemistry , pharmacology , engineering , alternative medicine , pathology

Grind and cure: Using the nonsteroidal anti‐inflammatory drug naproxen, a novel concept is demonstrated to dramatically enhance the rate of the recently discovered process of deracemization using abrasive grinding. The process relies on a gradual feed of the racemic target material by an in situ conversion.

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