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Fast Attrition‐Enhanced Deracemization of Naproxen by a Gradual In Situ Feed
Author(s) -
Noorduin Wim L.,
Kaptein Bernard,
Meekes Hugo,
van Enckevort Willem J. P.,
Kellogg Richard M.,
Vlieg Elias
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901386
Subject(s) - naproxen , grind , in situ , nonsteroidal , materials science , grinding , chemical engineering , process engineering , chemistry , nanotechnology , medicine , metallurgy , organic chemistry , pharmacology , engineering , alternative medicine , pathology
Grind and cure: Using the nonsteroidal anti‐inflammatory drug naproxen, a novel concept is demonstrated to dramatically enhance the rate of the recently discovered process of deracemization using abrasive grinding. The process relies on a gradual feed of the racemic target material by an in situ conversion.