Premium
CH Hydroxylation Using a Heterocyclic Catalyst and Aqueous H 2 O 2
Author(s) -
Litvinas Nichole D.,
Brodsky Benjamin H.,
Du Bois J.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901353
Subject(s) - hydroxylation , catalysis , aqueous solution , reactivity (psychology) , oxaziridine , chemistry , organic chemistry , medicinal chemistry , enzyme , medicine , alternative medicine , pathology
Substituted benzoxathiazines function as catalysts for the selective hydroxylation of tertiary CH bonds. Mechanistic studies have revealed an unanticipated disparity between oxaziridine reactivity and catalyst performance and have given way to a new catalyst and an aqueous H 2 O 2 reaction protocol that greatly facilitate such transformations (see scheme).