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Probing Dynamics within Amyloid Fibrils Using a Novel Capping Method
Author(s) -
Platt Geoffrey W.,
Xue WeiFeng,
Homans Steve W.,
Radford Sheena E.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901343
Subject(s) - heteronuclear single quantum coherence spectroscopy , amyloid fibril , molecular dynamics , beta 2 microglobulin , amyloid (mycology) , fibril , computer science , nuclear magnetic resonance spectroscopy , chemistry , computational biology , biochemistry , computational chemistry , stereochemistry , amyloid β , biology , medicine , inorganic chemistry , disease , pathology , immunology
Twist and shout : Dynamics within amyloid fibrils are probed using solution NMR spectroscopy (see 1 H– 15 N HSQC NMR spectra of wild‐type β 2 ‐microglobulin and a variant with an extended N‐terminal region). A novel method is employed to ensure the origin of NMR signals and to take molecular recycling from fibrils into account.