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Direct Michael, Aldol, and Mannich Additions Catalyzed by Alkaline Earth Metals
Author(s) -
Kazmaier Uli
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901261
Subject(s) - aldol reaction , alkaline earth metal , mannich reaction , catalysis , chemistry , michael reaction , organic chemistry , metal , inorganic chemistry
Trend‐setting : Alkaline earth metals are good catalysts for a number of direct addition reactions with carbonyl compounds. In Mannich reactions the stereochemical outcome can be controlled by the reaction conditions and the alkaline earth metal used (see scheme: Boc= tert ‐butoxycarbonyl, HMDS=hexamethyldisilazide).
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