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Highly Stereoselective One‐Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process
Author(s) -
Zhu Di,
Lu Min,
Dai Lu,
Zhong Guofu
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901249
Subject(s) - stereocenter , stereoselectivity , nitrone , intramolecular force , bicyclic molecule , cycloaddition , tandem , stereochemistry , combinatorial chemistry , computer science , chemistry , enantioselective synthesis , organic chemistry , catalysis , composite material , materials science
High five! A novel, facile, and highly stereoselective synthesis of the title compounds has been developed with the control of five stereogenic centers through an organocatalytic asymmetric one‐pot tandem process involving a diastereoselective intramolecular nitrone [3+2] cycloaddition (see scheme).