Highly Stereoselective One‐Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process | Zendy

Zhu Di | Zendy; Lu Min | Zendy; Dai Lu | Zendy; Zhong Guofu | Zendy

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Highly Stereoselective One‐Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process

Author(s) -

Zhu Di,

Lu Min,

Dai Lu,

Zhong Guofu

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901249

Subject(s) - stereocenter , stereoselectivity , nitrone , intramolecular force , bicyclic molecule , cycloaddition , tandem , stereochemistry , combinatorial chemistry , computer science , chemistry , enantioselective synthesis , organic chemistry , catalysis , composite material , materials science

High five! A novel, facile, and highly stereoselective synthesis of the title compounds has been developed with the control of five stereogenic centers through an organocatalytic asymmetric one‐pot tandem process involving a diastereoselective intramolecular nitrone [3+2] cycloaddition (see scheme).

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