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An Environmental DNA‐Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin
Author(s) -
King Ryan W.,
Bauer John D.,
Brady Sean F.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901209
Subject(s) - polyketide , cosmid , polyketide synthase , streptomyces , biology , gene , biosynthesis , genetics , computational biology , bacteria
A down to earth approach : Environmental (from desert soil) DNA derived cosmid clones containing type II polyketide synthase genes were screened for their ability to produce clone‐specific metabolites in Streptomyces. One of the Streptomyces recombinants produces erdacin ( 1 ), a polyketide with a previously unknown pentacyclic structure.