In Situ Assembly and Screening of Enzyme Inhibitors with Surface‐Tension Microarrays | Zendy

Mugherli Laurent | Zendy; Burchak Olga N. | Zendy; Balakireva Larissa A. | Zendy; Thomas Aline | Zendy; Chatelain François | Zendy; Balakirev Maxim Y. | Zendy

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In Situ Assembly and Screening of Enzyme Inhibitors with Surface‐Tension Microarrays

Author(s) -

Mugherli Laurent,

Burchak Olga N.,

Balakireva Larissa A.,

Thomas Aline,

Chatelain François,

Balakirev Maxim Y.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901139

Subject(s) - surface tension , phenylboronic acid , in situ , protease , microarray , enzyme , chemistry , materials science , biochemistry , organic chemistry , gene , physics , gene expression , quantum mechanics , catalysis

Hundreds of reactions were conducted in parallel in droplets maintained on a glass slide through differential surface tension in a new approach to submicroliter‐scale synthesis. This “surface‐tension microarray” was applied to the in situ assembly of thousands of derivatives of phenylboronic acid and their profiling against the NS3/4A protease of the hepatitis C virus. Several potent inhibitors of the enzyme were identified.

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