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Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold
Author(s) -
Coquière David,
Bos Jeffrey,
Beld Joris,
Roelfes Gerard
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901134
Subject(s) - enantioselective synthesis , substrate (aquarium) , scaffold , grafting , chemistry , catalysis , combinatorial chemistry , selectivity , optically active , biochemistry , organic chemistry , biology , computer science , polymer , ecology , database
Site creation : Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels–Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.