Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold | Zendy

Coquière David | Zendy; Bos Jeffrey | Zendy; Beld Joris | Zendy; Roelfes Gerard | Zendy

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Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

Author(s) -

Coquière David,

Bos Jeffrey,

Beld Joris,

Roelfes Gerard

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901134

Subject(s) - enantioselective synthesis , substrate (aquarium) , scaffold , grafting , chemistry , catalysis , combinatorial chemistry , selectivity , optically active , biochemistry , organic chemistry , biology , computer science , polymer , ecology , database

Site creation : Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels–Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.

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