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Copper‐Mediated Coupling of 1,1‐Dibromo‐1‐alkenes with Nitrogen Nucleophiles: A General Method for the Synthesis of Ynamides
Author(s) -
Coste Alexis,
Karthikeyan Ganesan,
Couty François,
Evano Gwilherm
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901099
Subject(s) - nucleophile , chemistry , nitrogen , dimethylformamide , combinatorial chemistry , coupling (piping) , copper , medicinal chemistry , organic chemistry , engineering , catalysis , solvent , mechanical engineering
Mild reaction conditions are the advantage of the title reaction, which allows straightforward entry to a variety of ynamides starting from readily available 1,1‐dibromo‐1‐alkenes, which act as attractive alkynylating agents (see scheme; EWG=electron‐withdrawing group, DMF= N , N ‐dimethylformamide).