Copper‐Mediated Coupling of 1,1‐Dibromo‐1‐alkenes with Nitrogen Nucleophiles: A General Method for the Synthesis of Ynamides | Zendy

Coste Alexis | Zendy; Karthikeyan Ganesan | Zendy; Couty François | Zendy; Evano Gwilherm | Zendy

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Copper‐Mediated Coupling of 1,1‐Dibromo‐1‐alkenes with Nitrogen Nucleophiles: A General Method for the Synthesis of Ynamides

Author(s) -

Coste Alexis,

Karthikeyan Ganesan,

Couty François,

Evano Gwilherm

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200901099

Subject(s) - nucleophile , chemistry , nitrogen , dimethylformamide , combinatorial chemistry , coupling (piping) , copper , medicinal chemistry , organic chemistry , engineering , catalysis , solvent , mechanical engineering

Mild reaction conditions are the advantage of the title reaction, which allows straightforward entry to a variety of ynamides starting from readily available 1,1‐dibromo‐1‐alkenes, which act as attractive alkynylating agents (see scheme; EWG=electron‐withdrawing group, DMF= N , N ‐dimethylformamide).

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