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Rhodium‐Mediated Decarboxylative Conjugate Addition of Fluorinated Benzoic Acids: Stoichiometric and Catalytic Transformations
Author(s) -
Sun ZhongMing,
Zhao Pinjing
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901097
Depending on the bisphosphine ligand , the decarboxylation of 2,6‐difluorinated benzoic acids with a Rh I catalyst in the presence of an acrylic ester or acrylamide led preferentially to conjugate addition (product 1 ) or Heck–Mizoroki arylation (product 2 ; binap=2,2′‐bis(diphenylphosphanyl)‐1,1′‐binaphthyl, diop=4,5‐bis(diphenylphosphanylmethyl)‐2,2‐dimethyl‐1,3‐dioxolane).