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Stereoselective Palladium‐Catalyzed Carboaminoxylations of Indoles with Arylboronic Acids and TEMPO
Author(s) -
Kirchberg Sylvia,
Fröhlich Roland,
Studer Armido
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901072
Subject(s) - palladium , stereoselectivity , catalysis , chemistry , organic chemistry , combinatorial chemistry
Indoles are not indolent : Various indoles react with arylboronic acids chemodivergently. CH arylation of free indole and N ‐methylindole gives the corresponding C(2)‐arylated indoles A whereas N‐acylated, N‐benzoylated, and N‐Boc‐protected indoles provide the corresponding arylcarboaminoxylated products B with excellent diastereoselectivity in good to excellent yields.