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Symmetry‐Guided Design and Fluorous Synthesis of a Stable and Rapidly Excreted Imaging Tracer for 19 F MRI
Author(s) -
Jiang ZhongXing,
Liu Xin,
Jeong EunKee,
Yu Yihua Bruce
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200901005
Subject(s) - magnetic resonance imaging , tracer , nuclear magnetic resonance , symmetry (geometry) , nuclear medicine , biomedical engineering , chemistry , physics , computer science , medicine , radiology , mathematics , nuclear physics , geometry
Getting FIT : A bispherical 19 F imaging tracer, 19 FIT, was designed and synthesized. 19 FIT is advantageous over perfluorocarbon‐based 19 F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as 19 FIT can lead to 19 F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by 1 H MRI in disease diagnosis.
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