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Multimodal Magnetic‐Resonance/Optical‐Imaging Contrast Agent Sensitive to NADH
Author(s) -
Tu Chuqiao,
Nagao Ryan,
Louie Angelique Y.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900984
Subject(s) - gadolinium , magnetic resonance imaging , contrast (vision) , nuclear magnetic resonance , computer science , isomerization , fluorescence , chemistry , nanotechnology , materials science , physics , medicine , artificial intelligence , optics , biochemistry , radiology , organic chemistry , catalysis
Agents get smart : A macrocycle‐based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r 1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.