Multistep Synthesis Using Modular Flow Reactors: Bestmann–Ohira Reagent for the Formation of Alkynes and Triazoles | Zendy

Baxendale Ian R. | Zendy; Ley Steven V. | Zendy; Mansfield Andrew C. | Zendy; Smith Christopher D. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Multistep Synthesis Using Modular Flow Reactors: Bestmann–Ohira Reagent for the Formation of Alkynes and Triazoles

Author(s) -

Baxendale Ian R.,

Ley Steven V.,

Mansfield Andrew C.,

Smith Christopher D.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200900970

Subject(s) - reagent , flow chemistry , cycloaddition , chemistry , alkyne , azide , modular design , combinatorial chemistry , alcohol , catalysis , continuous flow , copper , organic chemistry , computer science , programming language , physics , mechanics

Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three‐step oxidation/homologation/copper(I)‐catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research