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Multistep Synthesis Using Modular Flow Reactors: Bestmann–Ohira Reagent for the Formation of Alkynes and Triazoles
Author(s) -
Baxendale Ian R.,
Ley Steven V.,
Mansfield Andrew C.,
Smith Christopher D.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900970
Subject(s) - reagent , flow chemistry , cycloaddition , chemistry , alkyne , azide , modular design , combinatorial chemistry , alcohol , catalysis , continuous flow , copper , organic chemistry , computer science , programming language , physics , mechanics
Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three‐step oxidation/homologation/copper(I)‐catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).