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Non‐Hydrolyzable RNA–Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3′‐Peptidyl tRNA Termini
Author(s) -
Moroder Holger,
Steger Jessica,
Graber Dagmar,
Fauster Katja,
Trappl Krista,
Marquez Viter,
Polacek Norbert,
Wilson Daniel N.,
Micura Ronald
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900939
Subject(s) - transfer rna , rna , conjugate , peptide , chemistry , computational biology , biochemistry , combinatorial chemistry , biology , gene , mathematics , mathematical analysis
Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA–peptide conjugates that mimic peptidyl‐tRNA would be desirable, especially for ribosome structural biology. A flexible solid‐phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.