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Functionalized Templates for the Convergent Assembly of Polyethers: Synthesis of the HIJK Rings of Gymnocin A
Author(s) -
Van Dyke Aaron R.,
Jamison Timothy F.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900924
Subject(s) - template , epoxide , extension (predicate logic) , product (mathematics) , fragment (logic) , materials science , coupling (piping) , combinatorial chemistry , chemistry , nanotechnology , computer science , organic chemistry , catalysis , mathematics , composite material , algorithm , programming language , geometry
Extension ladder : The successful application of epoxide‐opening strategies towards the synthesis of ladder‐type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn=benzyl).