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Enzyme‐Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose
Author(s) -
Bernardos Andrea,
Aznar Elena,
Marcos María Dolores,
MartínezMáñez Ramón,
Sancenón Félix,
Soto Juan,
Barat José Manuel,
Amorós Pedro
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900880
Subject(s) - lactose , glycosidic bond , mesoporous material , mesoporous silica , moiety , hydrolysis , chemistry , grafting , chemical engineering , enzyme , materials science , nanotechnology , organic chemistry , engineering , polymer , catalysis
The great escape : A biocontrolled gated material has been prepared by grafting a lactose derivative onto the pore outlets of a mesoporous support. The galactosidase‐induced hydrolysis of the β1→4 glycosidic bond in the lactose moiety (red box in picture) allows the release of a dye entrapped in the pores of the hybrid material to the bulk solution.