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Stereochemistry Determination by Powder X‐Ray Diffraction Analysis and NMR Spectroscopy Residual Dipolar Couplings
Author(s) -
García Manuela E.,
Pagola Silvina,
NavarroVázquez Armando,
Phillips Damilola D.,
Gayathri Chakicherla,
Krakauer Henry,
Stephens Peter W.,
Nicotra Viviana E.,
Gil Roberto R.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900760
Subject(s) - chemistry , residual dipolar coupling , nuclear magnetic resonance spectroscopy , spectroscopy , powder diffraction , crystallography , coupling constant , lactol , nuclear magnetic resonance crystallography , x ray crystallography , diffraction , stereochemistry , fluorine 19 nmr , nuclear magnetic resonance , lactone , physics , particle physics , quantum mechanics , optics
A matter of technique : For a new steroidal lactol, jaborosalactol 24 ( 1 ), isolated from Jaborosa parviflora , NMR spectroscopy residual dipolar couplings and powder X‐ray diffraction analysis independently gave the same stereochemistry at C23–C26. Conventional NMR spectroscopic techniques, such as NOE and 3 J coupling‐constant analysis failed to unambiguously determine this stereochemistry.