Catalytic Asymmetric Mannich Reactions of Sulfonylacetates | Zendy

Cassani Carlo | Zendy; Bernardi Luca | Zendy; Fini Francesco | Zendy; Ricci Alfredo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Catalytic Asymmetric Mannich Reactions of Sulfonylacetates

Author(s) -

Cassani Carlo,

Bernardi Luca,

Fini Francesco,

Ricci Alfredo

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200900701

Subject(s) - deprotonation , sulfone , catalysis , carboxylate , combinatorial chemistry , chemistry , enantioselective synthesis , organic chemistry , organocatalysis , ion

Sulfone versus sulfone : Arylsulfonylacetates can be viewed as synthetic equivalents of a variety of α‐carboxylate anions. Phase‐transfer catalysis (PTC) enabled their mild deprotonation and catalytic asymmetric addition to highly reactive imines generated in situ from α‐amidosulfones (see scheme; Pg=protecting group). The synthetic utility of the products was demonstrated by their straightforward transformation into a range of β‐amino acid derivatives.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research