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Sequential and Modular Synthesis of Chiral 1,3‐Diols with Two Stereogenic Centers: Access to All Four Stereoisomers by Combination of Organo‐ and Biocatalysis
Author(s) -
Baer Katrin,
Kraußer Marina,
Burda Edyta,
Hummel Werner,
Berkessel Albrecht,
Gröger Harald
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900582
Subject(s) - stereocenter , aldol reaction , modular design , biocatalysis , computer science , combinatorial chemistry , chemistry , stereochemistry , enantioselective synthesis , organic chemistry , reaction mechanism , catalysis , programming language
Biocompatible : A modular chemoenzymatic synthesis (see scheme) based on asymmetric organo‐ and biocatalytic reaction sequences allows the sequential construction of both stereogenic centers of 1,3‐diols and leads to all four possible stereoisomers in enantiomerically pure form. The biocompatibility of the organocatalytic aldol reaction allows its direct use in the subsequent enzymatic reduction without the need for a work‐up step.