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Triggered Release of an Active Peptide Conjugate from a DNA Device by an Orally Administrable Small Molecule
Author(s) -
Taylor Steven K.,
Pei Renjun,
Moon Byoung C.,
Damera Srikanth,
Shen Aihua,
Stojanovic Milan N.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900499
Subject(s) - conjugate , tonic (physiology) , controlled release , peptide , chemistry , insulin , stereochemistry , pharmacology , medicine , biochemistry , endocrinology , mathematics , mathematical analysis
A real tonic : In a conceptually new approach to controlled release, the natural daily insulin profile in response to three meals is mimicked (see graph) with release of an insulin conjugate from a matrix, triggered by quinine, a component of tonic water.