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Asymmetric Syntheses of l,l ‐ and l,d ‐ Di‐ myo ‐inositol‐1,1′‐phosphate and their Behavior as Stabilizers of Enzyme Activity at Extreme Temperatures
Author(s) -
Longo Christina M.,
Wei Yang,
Roberts Mary F.,
Miller Scott J.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900480
Subject(s) - context (archaeology) , chemistry , enzyme , inositol , stereochemistry , inositol phosphate , biochemistry , receptor , biology , paleontology
The big “DIP”per : The preparation of both l,l ‐DIP and l,d ‐DIP (see structures) involves a complex case of double asymmetric induction in the key step of the synthesis. The differential ability of each isomer to contribute to thermoprotection in the context of a key enzyme has been assessed and both isomers of DIP are shown to possess biological activity.