Iron‐Catalyzed Chemoselective  ortho  Arylation of Aryl Imines by Directed CH Bond Activation | Zendy

Yoshikai Naohiko | Zendy; Matsumoto Arimasa | Zendy; Norinder Jakob | Zendy; Nakamura Eiichi | Zendy

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Iron‐Catalyzed Chemoselective ortho Arylation of Aryl Imines by Directed CH Bond Activation

Author(s) -

Yoshikai Naohiko,

Matsumoto Arimasa,

Norinder Jakob,

Nakamura Eiichi

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200900454

Subject(s) - chemistry , imine , aryl , reagent , acetophenone , bromide , catalysis , medicinal chemistry , sulfonate , palladium , selectivity , combinatorial chemistry , organic chemistry , sodium , alkyl

No Fe‐ar : Iron catalyzes an imine‐directed CH bond activation to introduce an ortho ‐aryl group to an acetophenone‐derived imine using a diarylzinc reagent (see scheme), whereas palladium catalyzes the conventional substitution reaction . The title reaction features mild and selective CH bond activation in the presence of aryl bromide, chloride, or sulfonate groups, and 1,2‐dichloroisobutane is essential to achieve such selectivity.

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