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From Metal Binding to Nanoparticle Formation: Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry
Author(s) -
Kang Sebyung,
Jolley Craig C.,
Liepold Lars O.,
Young Mark,
Douglas Trevor
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900437
Subject(s) - nanoparticle , chemistry , mass spectrometry , metal , particle size , phase (matter) , oxide , metal ions in aqueous solution , analytical chemistry (journal) , inorganic chemistry , nanotechnology , chromatography , materials science , organic chemistry
Mass measurements of metal‐mineralized protein cages allowed quantitative examination of the effects of metal‐ion concentration on the final nanoparticle size. Modeling using a kinetic master equation suggests that particle growth involves both a binding phase and a growth phase (see picture; I : relative abundance; LiDps: a DNA binding protein; n Fe: number of Fe atoms).