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Catalytic Cycloisomerization of 1,5‐Enynes to 1,3‐Cyclohexadienes via Ruthenium Vinylidene Intermediates
Author(s) -
Fukamizu Koji,
Miyake Yoshihiro,
Nishibayashi Yoshiaki
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900392
Subject(s) - cycloisomerization , ruthenium , catalysis , chemistry , combinatorial chemistry , diene , organic chemistry , natural rubber
Another way to dienes : The ruthenium‐catalyzed 6‐ endo ‐cycloisomerization of 1,5‐enynes gives the corresponding 1,3‐cyclohexadienes in high to excellent yields. This novel synthetic and catalytic method constitutes another way to selectively prepare 1,3‐cyclohexadienes, this cyclic diene skeleton being a core subunit in many natural products and a useful building block for a variety of organic transformations.