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A Microreactor with Thousands of Subcompartments: Enzyme‐Loaded Liposomes within Polymer Capsules
Author(s) -
Städler Brigitte,
Chandrawati Rona,
Price Andrew D.,
Chong SiowFeng,
Breheney Kerry,
Postma Almar,
Connal Luke A.,
Zelikin Alexander N.,
Caruso Frank
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900386
Subject(s) - microreactor , liposome , polymer , chemistry , nanotechnology , enzyme catalysis , materials science , enzyme , chemical engineering , biophysics , organic chemistry , catalysis , biology , engineering
Fully loaded : Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol‐modified polymers allows the preparation of capsosomes—liposome‐compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction confirmed the presence of active cargo within the capsosomes and was used to determine the number of subcompartments within this novel biomedical carrier system.