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A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo‐ and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines
Author(s) -
Sha Feng,
Huang Xian
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900212
Subject(s) - regioselectivity , aryne , combinatorial chemistry , chemistry , product (mathematics) , computer science , organic chemistry , catalysis , mathematics , geometry
Many components make light work : A novel synthetic strategy for the preparation of pyridines and isoquinolines in high chemo‐ and regioselectivity has been developed. By manipulating the reaction conditions, either product can be generated smoothly in a highly efficient and atom‐economic manner (see scheme).