Addition–Hydroamination Reactions of Propargyl Cyanamides: Rapid Access to Highly Substituted 2‐Aminoimidazoles

A valuable pharmacophore , the 2‐aminoimidazole moiety, can be accessed with a variety of substitution patterns through an addition–hydroamination–isomerization sequence (see scheme; R 1 ,R 4 ,R 5 =alkyl; R 3 =alkyl, aryl; R 2 =H, alkyl, aryl). The synthesis of the propargyl cyanamide precursors through a three‐component coupling enables the preparation of this important heterocyclic core structure in just three steps.