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One‐Pot, Direct Incorporation of [ 11 C]CO 2 into Carbamates
Author(s) -
Hooker Jacob M.,
Reibel Achim T.,
Hill Sidney M.,
Schueller Michael J.,
Fowler Joanna S.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900112
Subject(s) - chemistry , radiochemistry , nuclear chemistry , combinatorial chemistry
Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11 CO 2 with 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) has been developed for the synthesis of 11 C‐labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.