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Disterolphospholipids: Nonexchangeable Lipids and Their Application to Liposomal Drug Delivery
Author(s) -
Huang Zhaohua,
Jaafari Mahmoud Reza,
Szoka Francis C.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900111
Subject(s) - liposome , drug delivery , drug , chemistry , pharmacology , medicine , biochemistry , organic chemistry
Extreme makeover of cholesterol : Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer‐stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1 ) are valuable new components for liposome formulation.