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Bioinspired Colorimetric Detection of Calcium(II) Ions in Serum Using Calsequestrin‐Functionalized Gold Nanoparticles
Author(s) -
Kim Sunghyun,
Park Jeong Won,
Kim Dongkyu,
Kim Daejin,
Lee InHyun,
Jon Sangyong
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900071
Subject(s) - calsequestrin , calcium , colloidal gold , naked eye , nanoparticle , ion , precipitation , chemistry , nanotechnology , materials science , chromatography , detection limit , ryanodine receptor , organic chemistry , physics , meteorology
Abstract Seeing is sensing : Calsequestrin (CSQ) functionalized gold nanoparticles undergo calcium‐dependent CSQ polymerization, which results in a clear color change (see picture) together with precipitation. The sensing system is specific for Ca 2+ ions and the differences between normal and disease‐associated abnormal (hypercalcemia) Ca 2+ ion levels in serum can be distinguished with the naked eye.