Bioinspired Colorimetric Detection of Calcium(II) Ions in Serum Using Calsequestrin‐Functionalized Gold Nanoparticles | Zendy

Kim Sunghyun | Zendy; Park Jeong Won | Zendy; Kim Dongkyu | Zendy; Kim Daejin | Zendy; Lee InHyun | Zendy; Jon Sangyong | Zendy

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Bioinspired Colorimetric Detection of Calcium(II) Ions in Serum Using Calsequestrin‐Functionalized Gold Nanoparticles

Author(s) -

Kim Sunghyun,

Park Jeong Won,

Kim Dongkyu,

Kim Daejin,

Lee InHyun,

Jon Sangyong

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200900071

Subject(s) - calsequestrin , calcium , colloidal gold , naked eye , nanoparticle , ion , precipitation , chemistry , nanotechnology , materials science , chromatography , detection limit , ryanodine receptor , organic chemistry , physics , meteorology

Seeing is sensing : Calsequestrin (CSQ) functionalized gold nanoparticles undergo calcium‐dependent CSQ polymerization, which results in a clear color change (see picture) together with precipitation. The sensing system is specific for Ca 2+ ions and the differences between normal and disease‐associated abnormal (hypercalcemia) Ca 2+ ion levels in serum can be distinguished with the naked eye.

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