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A Supramolecular Approach for Preparation of Size‐Controlled Nanoparticles
Author(s) -
Wang Hao,
Wang Shutao,
Su Helen,
Chen KuanJu,
Armijo Amanda Lee,
Lin WeiYu,
Wang Yanju,
Sun Jing,
Kamei Kenichiro,
Czernin Johannes,
Radu Caius G.,
Tseng HsianRong
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200900063
Subject(s) - supramolecular chemistry , biodistribution , adamantane , positron emission tomography , nanoparticle , materials science , nanotechnology , in vivo , chemistry , crystallography , biology , nuclear medicine , organic chemistry , crystal structure , medicine , genetics
A supramolecular approach has been developed for the preparation of supramolecular nanoparticles (SNPs) with variable sizes (30–450 nm) from three different molecular building blocks using a cyclodextrin/adamantane recognition system. Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture).