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Inside Cover: Highly Selective Metal Catalysts for Intermolecular Carbenoid Insertion into Primary CH Bonds and Enantioselective CC Bond Formation (Angew. Chem. Int. Ed. 50/2008)
Author(s) -
Thu HungYat,
Tong Glenna SoMing,
Huang JieSheng,
Chan Sharon LaiFung,
Deng QingHai,
Che ChiMing
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890257
Subject(s) - carbenoid , chemistry , carbene , catalysis , steric effects , porphyrin , enantioselective synthesis , rhodium , intermolecular force , selectivity , stereochemistry , medicinal chemistry , polymer chemistry , crystallography , photochemistry , organic chemistry , molecule
Analogous to a microreactor that has twelve inlets, but with only one large enough for secondary CH bonds to approach reactive metal–carbene groups, a rhodium catalyst bearing a bis‐pocket porphyrin that imposes a high steric hindrance to secondary CH bonds is described by C.‐M. Che et al. in their Communication on page 9747 ff. The porphyrin directs reactions to occur at the less reactive primary CH bonds of n ‐alkanes, with an approximate primary/secondary selectivity of 11:1.