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Cover Picture: Chemical Strategies for Generating Protein Biochips (Angew. Chem. Int. Ed. 50/2008)
Author(s) -
Jonkheijm Pascal,
Weinrich Dirk,
Schröder Hendrik,
Niemeyer Christof M.,
Waldmann Herbert
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890256
Subject(s) - biochip , protein microarray , cover (algebra) , chemistry , surface protein , nanotechnology , computational biology , biochemistry , microbiology and biotechnology , microarray , biophysics , biology , materials science , gene , engineering , gene expression , mechanical engineering , virology
Chemistry has become a powerful tool in protein biochip generation by providing methods to specifically functionalize proteins and immobilize them on surfaces. C. M. Niemeyer, H. Waldmann, and co‐workers outline the range of available chemical methods for preparation of high‐quality protein biochips in the Review on page 9618 ff. The cover picture shows the sequence of events in a protein microarray protein–protein interaction assay: two different proteins are immobilized through specific interactions with the surface; a third, fluorescently labeled protein is used for read‐out.