Premium
Cover Picture: Solid‐Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2 (Angew. Chem. Int. Ed. 49/2008)
Author(s) -
Pattabiraman Vijaya R.,
McKinnie Shaun M. K.,
Vederas John C.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890251
Subject(s) - lantibiotics , peptide , cover (algebra) , desmethyl , chemistry , bacteria , combinatorial chemistry , stereochemistry , antimicrobial , bacteriocin , biochemistry , biology , organic chemistry , engineering , genetics , mechanical engineering , metabolite
A two‐peptide lantibiotic … is active against certain pathogenic bacteria in nanomolar concentrations. In their Communication on page 9472 ff., J. C. Vederas and co‐workers describe the first solid‐supported synthesis of lacticin 3147, the bis(desmethyl) analogue of lacticin A2. This compound shows potent synergistic antimicrobial activity in the presence of lacticin A1. Other lantibiotics can be prepared for the study of structure–activity relationships by using this strategy. Annie Tykwinski is thanked for the cover graphic design.