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Inside Cover: Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones (Angew. Chem. Int. Ed. 41/2008)
Author(s) -
Schuler Marie,
Silva Franck,
Bobbio Carla,
Tessier Arnaud,
Gouverneur Véronique
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890202
Subject(s) - selectfluor , protonation , catalysis , cover (algebra) , reagent , chemistry , electrophile , combinatorial chemistry , organic chemistry , engineering , ion , mechanical engineering
Gold(I) catalysts teamed with selectfluor produce trifluorinated dihydropyranones from difluoroynones under mild conditions, as described by V. Gouverneur et al. in the Communication on page 7927 ff. The process proceeds via a vinylgold intermediate that undergoes fluorination and competing protonation. This gold chemistry is encouraging for the synthesis of architecturally complex fluorinated targets combining fluorinated precursors with electrophilic fluorinating reagents. The illustration was produced by Dr. Karl Harrison (University of Oxford)