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Inside Cover: Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria (Angew. Chem. Int. Ed. 40/2008)
Author(s) -
Ziemert Nadine,
Ishida Keishi,
Liaimer Anton,
Hertweck Christian,
Dittmann Elke
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890196
Subject(s) - depsipeptide , cyanobacteria , ribosomal rna , stereochemistry , chemistry , biology , bacteria , biochemistry , gene , genetics
Cage‐like depsipeptides are investigated by C. Hertweck, E. Dittmann, and co‐workers in their Communication on page 7756 ff. The cyanobacterial protease inhibitors microviridin B and J are synthesized from ribosomally produced prepeptides that are transformed into tricyclic depsipeptides. The picture shows a microviridin‐producing cyanobacteria toxic bloom on a lake surface, together with a schematic representation of ribosomal protein biosynthesis and tricyclic depsipeptide cage structures.