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Cover Picture: Primary‐Amine‐Catalyzed Enantioselective Intramolecular Aldolizations (Angew. Chem. Int. Ed. 40/2008)
Author(s) -
Zhou Jian,
Wakchaure Vijay,
Kraft Philip,
List Benjamin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890195
Subject(s) - enantioselective synthesis , intramolecular force , int , cover (algebra) , amine gas treating , catalysis , primary (astronomy) , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , computer science , physics , engineering , programming language , mechanical engineering , astronomy
Liquorice or celery the catalyst decides! The two enantiomers of celery ketone differ strongly in their scent, and both can be made from the same symmetric diketone precursor by using a new organocatalytic aldol reaction. The enantiogroup‐selective intramolecular aldolization of 4‐propylheptane‐2,6‐dione provides either the S enantiomer, which smells of liquorice, or the potent R enantiomer, which determines the celery odor of the racemate. For details, see the Communication by B. List and co‐workers on page 7656 ff.