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Cover Picture: The Continuing Saga of the Marine Polyether Biotoxins (Angew. Chem. Int. Ed. 38/2008)
Author(s) -
Nicolaou K. C.,
Frederick Michael O.,
Aversa Robert J.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890185
Subject(s) - marine toxin , dinoflagellate , ciguatera , ciguatoxin , biology , chemistry , computational biology , toxin , microbiology and biotechnology , ecology , fish <actinopterygii> , fishery
An odyssey is described by K. C. Nicolaou et al. in their Review on page 7182 ff.: From the isolation of the first marine biotoxin with a ladder structure, brevetoxin B, in 1981 to the synthesis of maitotoxin molecule domains. Pictured is the dinoflagellate Gambierdiscus toxicus (small circle; courtesy of Steve L. Morton, NOAA), a unicellular marine organism producing maitotoxin, the largest and most toxic, non‐proteomic secondary metabolite isolated to date. The surgeonfish (moodboard/Corbis) serves as a carrier of this neurotoxin to humans through the food chain causing ciguatera poisoning.