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Inside Cover: Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores (Angew. Chem. Int. Ed. 30/2008)
Author(s) -
Mitchell Nick,
Howorka Stefan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890145
Subject(s) - nanopore , dna , cover (algebra) , nanopore sequencing , signal (programming language) , nanotechnology , cover story , chemistry , combinatorial chemistry , biophysics , computer science , materials science , biology , engineering , dna sequencing , biochemistry , mechanical engineering , programming language
Chemical tags help detect separate bases in individual DNA strands, as demonstrated by S. Howorka and N. Mitchell in the Communication on page 5565 ff. In the sensing strategy, a single DNA strand is threaded through a “nanotunnel”. Owing to their larger diameter, individual bases with attached chemical tags are slowed at the narrow constriction. The pattern of modified and unmodified bases gives rise to a characteristic current signal for the DNA. The picture was prepared by Hugh Martin.