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Inside Cover: Total Synthesis of (±)‐Axinellamines A and B (Angew. Chem. Int. Ed. 19/2008)
Author(s) -
O'Malley Daniel P.,
Yamaguchi Junichiro,
Young Ian S.,
Seiple Ian B.,
Baran Phil S.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890085
Subject(s) - total synthesis , pyrrole , cover (algebra) , imidazole , int , amine gas treating , chemistry , class (philosophy) , combinatorial chemistry , stereochemistry , computer science , organic chemistry , engineering , programming language , mechanical engineering , artificial intelligence
Chemoselective by design is the total synthesis of marine pyrrole–imidazole alkaloids of the axinellamine/palau'amine/massadine class described by P. S. Baran and co‐workers in their Communication on page 3581 ff. Their approach features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.