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Cover Picture: Tip‐Enhanced Raman Spectroscopy of Single RNA Strands: Towards a Novel Direct‐Sequencing Method (Angew. Chem. Int. Ed. 9/2008)
Author(s) -
Bailo Elena,
Deckert Volker
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890029
Subject(s) - raman spectroscopy , rna , biomolecule , dna , cover (algebra) , nucleobase , dna sequencing , cytosine , chemistry , biophysics , nanotechnology , materials science , biology , biochemistry , optics , physics , gene , mechanical engineering , engineering
Tip‐enhanced Raman spectroscopy (TERS) provides high lateral resolution, down to a few nucleobases in a single RNA strand of a cytosine homopolymer. A silver‐coated nanotip which can be positioned with high precision serves as a Raman enhancer. TERS spectra are obtained by positioning the tip along the RNA strand. As E. Bailo and V. Deckert show in their Communication on page 1658 ff., the sensitivity obtained suggests that, with TERS, the direct and label‐free sequencing of biomolecules, such as DNA, RNA, or peptides, is feasible.