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Cover Picture: DNA Minicircles with Gaps for Versatile Functionalization / Construction of DNA Architectures with RNA Hairpins (Angew. Chem. Int. Ed. 5/2008)
Author(s) -
Rasched Goran,
Ackermann Damian,
Schmidt Thorsten L.,
Broekmann Peter,
Heckel Alexander,
Famulok Michael,
Mayer Günter,
Kuhn Nicole
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200890008
Subject(s) - minicircle , heteroduplex , oligonucleotide , dna , nucleic acid , rna , nucleotide , nucleic acid thermodynamics , duplex (building) , biophysics , chemistry , biology , computational biology , genetics , base sequence , gene
Bind the gap … … The cover picture shows an idealized rendering of a DNA minicircle (green) with a 21‐nucleotide‐long single‐stranded region, or gap. M. Famulok and co‐workers show in their Communication on page 967 ff. how these circles can be generated and visualized by atomic force microscopy. Any complementary oligonucleotide (red) can hybridize to the gap so that synthetic functional groups can be incorporated. In a second study on page 971 ff. they show that RNA molecules can also hybridize to form a heteroduplex with the gap, enabling the incorporation of nucleic acid motifs in DNA minicircles.