Premium
Iridium Catalysis for CH Bond Arylation of Heteroarenes with Iodoarenes
Author(s) -
Join Benoît,
Yamamoto Takuya,
Itami Kenichiro
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806358
Subject(s) - iridium , catalysis , ligand (biochemistry) , chemistry , combinatorial chemistry , construct (python library) , coupling (piping) , coupling reaction , organic chemistry , materials science , computer science , metallurgy , biochemistry , receptor , programming language
Efficient couplings using equimolar quantities of each coupling partner and multiple CH bond arylation reactions are achieved with an Ir‐based catalytic system for the CH bond arylation of electron‐rich heteroarenes with iodoarenes to construct extended π‐systems. The dramatic ligand effect on reaction efficiency leads to the discovery that Crabtree's catalyst (see scheme) is the optimal catalyst precursor.