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Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars
Author(s) -
Chang Pamela V.,
Chen Xing,
Smyrniotis Chris,
Xenakis Alexander,
Hu Tianshun,
Bertozzi Carolyn R.,
Wu Peng
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806319
Subject(s) - sialic acid , glycoprotein , biochemistry , identification (biology) , chemistry , biology , computational biology , botany
Sialome sweet sialome : As sialic acids are involved in many host–pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N ‐(4‐pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.