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Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology
Author(s) -
Nielsen Jakob T.,
Arar Khalil,
Petersen Michael
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806244
Subject(s) - tetrad , folding (dsp implementation) , nucleic acid , topology (electrical circuits) , g quadruplex , dna , chemistry , sequence (biology) , guanine , crystallography , biology , biochemistry , genetics , mathematics , nucleotide , combinatorics , gene , electrical engineering , engineering
Sharp curves : The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V‐shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology.